Synergistic thrombotic risk of antibodies against phosphatidylserine and prothrombin and β-2-glycoprotein I

Abstract

Background: Coagulation and anticoagulation systems are good targets of antiphospholipid antibodies. We assessed the contribution of the antiphospholipid antibodies to the thrombotic risk. Methods: Enzyme-linked immunosorbent assays on antibodies against phosphatidylserine and prothrombin (PS/PT), protein C, protein S, protein Z, and thrombomodulin were performed in 164 patients who showed positive results for lupus anticoagulant or anticardiolipin antibody. Results: Anti-β-2- glycoprotein I (β2GPI) and anti-PS/PT were significant risk factors for thrombotic events (P