Journal ArticleOPEN ACCESS

Interleukin-2 expands neuroprotective regulatory T cells in Parkinson’s disease

  • Markovic M
  • Yeapuri P
  • Namminga K
  • et al.
NeuroImmune Pharmacology and Therapeutics (2022) 1(1) 43-50
DOI: 10.1515/nipt-2022-0001
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Abstract

Background: Pharmacological approaches that boost neu-roprotective regulatory T cell (Treg) number and function lead to neuroprotective activities in neurodegenerative disorders. Objectives: We investigated whether low-dose interleukin 2 (IL-2) expands Treg populations and protects nigrostriatal dopaminergic neurons in a model of Parkinson's disease (PD).

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Markovic, M., Yeapuri, P., Namminga, K. L., Lu, Y., Saleh, M., Olson, K. E., … Mosley, R. L. (2022). Interleukin-2 expands neuroprotective regulatory T cells in Parkinson’s disease. NeuroImmune Pharmacology and Therapeutics, 1(1), 43–50. https://doi.org/10.1515/nipt-2022-0001

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