A novel 1: 1 Complex of potassium mikanin-3-O-sulfate with methanol

Abstract

Mikanin-3-O-sulfate (1), in the form of its potassium salt, together with mikanin (2) and alpinetin (3) were isolated from Mikania micrantha. The crystal structures of K(1)·CH3OH, 2 and 3· H2O were established by X-ray crystallography. The potassium ions in K(1)·CH3OH are bridged by 05, 07 and 08 to form a chain of face-sharing KO8 coordination polyhedra, from which the aglycon units are outstretched to form a polymeric molecular column. Adjacent molecular columns are linked by π-π stacking between parallel, intercalating aglycon units to form layers matching the (101̄) family of planes, which are further interconnected into a three-dimensional supramolecular assembly. Sulfation at 3-OH induced better co-planarity and conjugation of the rings.