Formulation and evaluation of a topical gel containing dapsone and fexofenadine HCl

Abstract

Topical drug administration is a localized  method of delivering drugs to specific areas of the body via topical channels such as ophthalmic, rectal, vaginal, and cutaneous. The major route of topical medication delivery is through the skin, which is one of the most easily accessible organs on the human body for topical drug administration. The present investigation involves formulation of topical gel using Dapsone and Fexofenadine HCl. For the treatment of chronic spontaneous urticaria, Dapsone is an effective and well-tolerated second-line treatment. Topical Dapsone is used to treat acne . Dapsone belongs to the sulfone antibiotics family of drugs. It works by reducing inflammation and delaying or preventing bacteria growth. Fexofenadine  HCl is an antihistamine medicine that helps with the symptoms of allergies.Topical gel of Dapsone and FexofenadineHCl was prepared by using High molecular weight water soluble polymer Hydroxy propyl methyl cellulose such as K35 grade and other excipients including Propyl paraben, oleic acid, Triethanaloamine and purified water were reported in the formation of gel. In the present investigation combination of Dapsone and Fexofenadine HCl gel.