Skip to main content

Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer's disease with PET imaging agents 18 F-flutemetamol and 18 F-florbetaben

5Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

This artice is free to access.

Abstract

Background: Although amyloid beta (Aβ) imaging is widely used for diagnosing and monitoring Alzheimer's disease in clinical fields, paralleling comparison between 18 F-flutemetamol and 18 F-florbetaben was rarely attempted in AD mouse model. We performed a comparison of Aβ PET images between 18 F-flutemetamol and 18 F-florbetaben in a recently developed APPswe mouse model, C57BL/6-Tg (NSE-hAPPsw) Korl. Results: After an injection (0.23mCi) of 18 F-flutemetamol and 18 F-florbetaben at a time interval of 2-3days, we compared group difference of SUVR and kinetic parameters between the AD (n=7) and control (n=7) mice, as well as between 18 F-flutemetamol and 18 F-florbetaben image. In addition, bio-distribution and histopathology were conducted. With visual image and VOI-based SUVR analysis, the AD group presented more prominent uptake than did the control group in both the 18 F-florbetaben and 18 F-flutemetamol images. With kinetic analysis, the 18 F-florbetaben images showed differences in K1 and k4 between the AD and control groups, although 18 F-flutemetamol images did not show significant difference. 18 F-florbetaben images showed more prominent cortical uptake and matched well to the thioflavin S staining images than did the 18 F-flutemetamol image. In contrast, 18 F-flutemetamol images presented higher K1, k4, K1/k2 values than those of 18 F-florbetaben images. Also, 18 F-flutemetamol images presented prominent uptake in the bowel and bladder, consistent with higher bio-distribution in kidney, lung, blood and heart. Conclusions: Compared with 18 F-flutemetamol images, 18 F-florbetaben images showed prominent visual uptake intensity, SUVR, and higher correlations with the pathology. In contrast, 18 F-flutemetamol was more actively metabolized than was 18 F-florbetaben (Son et al. in J Nucl Med 58(Suppl 1):S278, 2017].

Cite

CITATION STYLE

APA

Son, H. J., Jeong, Y. J., Yoon, H. J., Lee, S. Y., Choi, G. E., Park, J. A., … Kang, D. Y. (2018). Assessment of brain beta-amyloid deposition in transgenic mouse models of Alzheimer’s disease with PET imaging agents 18 F-flutemetamol and 18 F-florbetaben. BMC Neuroscience, 19(1). https://doi.org/10.1186/s12868-018-0447-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free