Effects of vancomycin linoleic acid nanoparticles on male reproductive indices of Sprague–Dawley rats

Abstract

The management of bacterial infections, especially trains of methicillin-resistant Staphylococcus aureus observe in health care settings, has markedly improved with the introduction of established drugs but using newer nano-based formulations. This study investigates the effects of vancomycin-linoleic acid nanoparticles on testicular tissue in an experimental animal model. Twenty-five adult male Sprague–Dawley rats maintained at the Animal House of the Biomedical Resources Unit were assigned to five groups namely E–solid lipid nanoparticles; F–vancomycin solid lipid nanoparticle; G–linoleic acid nanoparticle; H–vancomycin linoleic acid; and A–control. Perturbations in seminal fluid parameters showed a reduced sperm count in groups F & G which was statistically significant (p.05). There was also increased luteinizing hormone (LH) and decreased in follicular stimulating hormone (FSH) levels was statistically significant (p