67PD Quality of life after risk-reducing salpingo-oophorectomy in BRCA carrier

Abstract

Background: Risk-reducing salpingo-oophorectomy (RRSO) is generally recommended for women with BRCA1 or BRCA2 mutation at age 35 and more. However, the menopause symptoms induced by RRSO may decrease quality of life (QOL). In Korea, the influence of RRSO to carrier's QOL has not been evaluated. This study was designed to compare the QOL and menopausal symptoms between RRSO and non-RRSO group. We also evaluated the change of QOL before and after RRSO among subgroup who had RRSO. Methods: Total of 45 women with BRCA1 or BRCA2 mutation at age 35 and more were included in this study. Outcomes were measured using the forms including SF-36v2 for QOL, STAI-1 for anxiety, Beck Depression inventory for depression, LOT-R for optimism, CAREs for sexual function and MRS for menopausal symptoms. This study was approved by the institutional review board of Seoul National University Bundang Hospital. Results: In total, 26 women underwent RRSO and 19 women did not. The mean age in RRSO group (49.0 years) was statistically higher than that in non-RRSO group (42.7 years). However, other demographic factors (age, education, income, occupation, marital status, family history, and underlying disease) were not different between two groups. The scores for mental QOL, depression, optimism, sexual function and menopause were similar between RRSO and non-RRSO groups. Only physical QOL in non-RRSO group (62.2) was higher than that in RRSO group (56.3), with a trend toward significance (p=0.07). Among 26 women with RRSO, 11 were evaluated for QOL and psychological status before RRSO. As a result of analyzing, the change of QOL and emotional status before and after RRSO among the 11 women, only physical QOL after RRSO (57.4) was significantly higher than before RRSO (45.1) (p=0.004). Conclusions: Our study did not show a significant difference in QOL and menopausal symptoms according to RRSO. Only physical QOL was significantly improved after surgery among subgroup with RRSO.