Room temperature lewis base-catalyzed alumination of terminal alkynes

Abstract

An efficient and mild access to mixed dimethylalkynylaluminum reagents has been developed via a direct Lewis base-catalyzed alumination of terminal alkynes by trimethylaluminum. The use of bis(trimethylsilyl)methylamine enables the metalation at room temperature with only 1% of catalyst loading. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.