Enantioselective synthesis of cyclic amino alcohols: Cis-1-amino-2-indanol

Abstract

(1S,2R)-cis-1-Amino-2-indanol has been synthesized. A unique feature of the synthesis involves securing the functionalities and the configurations of the two Stereocenters on an acyclic precursor before cyclizing it into the final ring-skeleton. The strategy allows both the Stereocenters to be controlled in an absolute manner.