Therapeutic Effects of Oxytetracycline Trial Tablets against Vibriosis in Cultured Kuruma Prawns Penaeus Japonicus Bate

Abstract

The in vitro antibacterial action of oxytetracycline (OTC) against Vibrio sp., the effective dose in vivo and the therapeutic effect in the field using trial tablets containing OTC were investigated to establish measures for elimination of a disease caused by Vibrio sp. which is epidemic in cultured kuruma prawns.The minimal inhibitory concentration of OTC against 49 strains of Vibrio sp. were <0.1-12.5 mcg/ml. The optimum dose of OTC tablets in vivo was assumed to be 25 or 50 mg/kg b.w./day of OTC. Administration of 50 or 100 mg/kg b.w./day of OTC in tablet form for 4-6 days to prawns with the disease in the field showed excellent therapeutic effects at both doses. © 1985, The Japanese Society of Fisheries Science. All rights reserved.