Piperidine mediated synthesis of prenylated chalcones and 8-substituted-2, 5-dihydro-2-(4-tolybenzo)-5-(3-methylbut-2-enyloxy) phenol-1, 5-benzothiazepines and its derivatives as anti cancer agents

Abstract

1, 5-benzothiazepine is the main seven-membered heterocyclic ring system and having several cardiac, psychotherapeutic activities. Which has been synthesized by a catalytic amount of piperidine mediated condensation of dry toluene with 5-substituted-2-Amino benzenethiols (2) and Prenyloxy chalcones (3). The corresponding prenyloxy chalcones (3) were synthesized by piperidine mediated claisen-Schmidt condensation of an ethanolic solution of 4-prenyloxy 2-hydroxy acetophenone (1) with aromatic aldehydes. It was planned to use a weaker base like piperidine instead of using a strong base to enhance the better yields. The structures have been established on the basis of elemental (C, H, N) analysis, IR, 1H NMR, Mass spectral data. The compounds (3) and (5) were screened for antimicrobial activities against a variety of bacterial agent. The anti-oxidative activities were also determined.