The prelude on conventional and advance treatment of pemphigus vulagaris (PV): A review

Abstract

The Pemphigus vulgaris (PV) is a group of highly lethal autoimmune disease characterized by mucocutaneous erosions or blisters. Pemphigus vulgaris can be present in different forms like oral and topical. So, it is challenging to manage and treat. Mortality rate due to Pemphigus vulgaris can be decreased by using systemic corticosteroids, but the present treatment options are limited due to the toxicity profiles of drugs available for treating Pemphigus vulgaris. Recent studies that shed light on the molecular mechanisms involved in the disease had lead to introduction of advance therapies like immunoadsorption, extracorporeal photochemotherapy (ECP), tumor Necrosis Factor-α (TNF-α) treatment and few other treatments have been subject to randomized control trials to firmly establishes therapeutic efficacy. The present review emphasized on management of the condition, most commonly conventional treatments and recent treatment advances.