In vitro activity of cefpodoxime proxetil (U-76,252; CS-807) agaisnt Neisseria gonorrhoeae

Abstract

Cefpodoxime proxetil is an oral cephalosporin antibiotic. The in vitro activities of cefpodoxime (the active metabolite of cefpodoxime proxetil), ceftriaxone, and cefuroxime against both antibiotic-susceptible and antibiotic-resistant clinical isolates of Neisseria gonorrhoeae were determined. Cefpodoxime inhibited all penicillin-susceptible strains and penicillinase-producing stains at ≤0.015 μg/ml; chromosomally resistant strains were inhibited by cefpodoxime at ≤0.125 μg/ml.