Further bisabolenes and dammarane triterpenes of Commiphora kua resin

Abstract

From the resins of Commiphora kua a novel bisabolene; 6-hydroxy-2-methyl-5- (5′-hydroxy-1′(R),5′-dimethylhex-3′-enyl)-phenol together with two new dammarane triterpenes, 3β,16β,20(S),25- tetrahydroxydammar-23-ene and 3β-acetoxy-16β,20(S),25- trihydroxydammar-23-ene, have been isolated. In addition, being reported are known compounds identified as 2-methyl-5-(4′(S)-hydroxy-1′(R), 5′-dimethylhex-5′-enyl)-phenol, 2-acetoxyfuranodienone, 2-methoxyfuranodienone, 3β,16β,20(R)-trihydroxydammar-24-ene and its acetate derivative, 3β-acetoxy-16β,20(R)-dihydroxydammar-24-ene, and β-amyrin and its acetate derivative. 2-Methyl-5-(4′(S)-hydroxy- 1′(R),5′-dimethylhex-5′-enyl)-phenol displayed fungicidal activity against Cladosporium cucumernum on TLC assay. © 2003 Pharmaceutical Society of Japan.