Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

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Abstract

A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified. © 2009 Elsevier Ltd. All rights reserved.

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Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., … Feng, Y. (2009). Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors. Bioorganic and Medicinal Chemistry Letters, 19(23), 6686–6690. https://doi.org/10.1016/j.bmcl.2009.09.115

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