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A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer

Journal of Cell Biology
DOI: 10.1083/JCB.201904119
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Abstract

PTEN loss stimulates prostate tumor progression by sustaining AKT activation. Nowak et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb. 201902048) surprisingly show that the AKT-suppressing phosphatase PHLPP2 promotes disease progression in the context of dual PTEN and p53 loss by increasing MYC stability.

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Toivanen, R., & Furic, L. (2019, June 3). A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/JCB.201904119

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