Motoric cognitive risk syndrome

Abstract

ABSTRACT\rObjectives: Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a\rnewly described predementia syndrome characterized by slow gait and cognitive complaints, in\rmultiple countries, and its association with dementia risk.\rMethods: Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia\rand disability aged 60 years and older from 22 cohorts from 17 countries. We also examined\rrisk of incident cognitive impairment (Mini-Mental State Examination decline $4 points) and\rdementia associated with MCR in 4,812 individuals without dementia with baseline MiniMental\rState Examination scores $25 from 4 prospective cohort studies using Cox models\radjusted for potential confounders.\rResults: At baseline, 2,808 of the 26,802 participants met MCR criteria. Pooled MCR prevalence\rwas 9.7% (95% confidence interval [CI] 8.2%–11.2%). MCR prevalence was higher with older\rage but there were no sex differences. MCR predicted risk of developing incident cognitive\rimpairment in the pooled sample (adjusted hazard ratio [aHR] 2.0, 95% CI 1.7–2.4); aHRs were\r1.5 to 2.7 in the individual cohorts. MCR also predicted dementia in the pooled sample (aHR 1.9,\r95% CI 1.5–2.3). The results persisted even after excluding participants with possible cognitive\rimpairment, accounting for early dementia, and diagnostic overlap with other predementia\rsyndromes.\rConclusion: MCR is common in older adults, and is a strong and early risk factor for cognitive\rdecline. This clinical approach can be easily applied to identify high-risk seniors in a wide variety\rof settings