Investigation of association between slime production by Candida Spp and susceptibility to fluconazole and voriconazole

Abstract

Purpose: To determine the susceptibilities of fluconazole and voriconazole based on slime production by Candida spp. Methods: Candida strains (115) isolated in the period between January 2011 and January 2012 were included in this study. Conventional methods were used for the identification. Candida albicans and non-C. albicans isolates were tested for slime production with modified tube adherence test and antifungal resistance with disk diffusion method. Results: Slime positivity was 31.3% in all Candida species. Slime positivity in non-C.albicans isolates (44.89%) was higher than in C. albicans species (21.21%). All C. albicans isolates were sensitive to fluconazole and voriconazole. The highest resistance to fluconazole (40%) and voriconazole (5%) was by C. glabrata strains. Conclusion: Species definition and determination of antifungal susceptibility patterns are advised for the proper management and treatment of patients. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.