Antiviral activity of chaenomeles sinensis against influenza a/chiba/1001/2009 (h1n1) pdm virus

Abstract

We previously reported that a polyphenol-rich fraction, CSD3, of the fruit of Chaenomeles sinensis neutralizes seasonal influenza viruses. In this study, we examined whether CSD3 possesses antiviral activities against the H1N1 virus of swine origin that caused a global pandemic in 2009. Treatment of the pandemic influenza virus, A/Chiba/1001/2009 (H1N1) pdm, with CSD3 at 250 μg/ml decreased viral infectivity by 1/3 000. This indicates that the anti-viral components in C. sinensis are also effective against the 2009 pandemic influenza virus. In addition, infectivity was suppressed five times more than hemagglutinating activity with CSD3 treatment at 5 μg/ml, suggesting that CSD3 inhibits at multiple steps of infection, particularly the steps after adsorption.