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MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression

Cell Reports (2020) 33(2)
DOI: 10.1016/j.celrep.2020.108267
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Abstract

Bruschetta et al., show that MC4R neurons in the dorsal raphe nucleus are inhibited by α-MSH. Inhibition of melanocortin signaling decreases feeding and increases 5-HT turnover, resulting in increased anxiety and depression-like behavior.

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Bruschetta, G., Jin, S., Liu, Z. W., Kim, J. D., & Diano, S. (2020). MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression. Cell Reports, 33(2). https://doi.org/10.1016/j.celrep.2020.108267

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