Efferocytosis during myocardial infarction

20Citations
Citations of this article
24Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Myocardial infarction is one of the major causes of death worldwide. Many heart cells die during myocardial infarction through various processes such as necrosis, apoptosis, necroptosis, autophagy-related cell death, pyroptosis and ferroptosis. These dead cells in infarcted hearts expose the so-called 'eat-me' signals, such as phosphatidylserine, on their surfaces, enhancing their removal by professional and non-professional phagocytes. Clearance of dead cells by phagocytes in the diseased hearts plays a crucial role in the pathology of myocardial infarction by inhibiting the inflammatory responses caused by the leakage of contents from dead cells. This review focuses on the rapidly growing understanding of the molecular mechanisms of dead cell phagocytosis, termed efferocytosis, during myocardial infarction, which contributes to the pathophysiology of myocardial infarction.

Cite

CITATION STYLE

APA

Yoshimura, C., Nagasaka, A., Kurose, H., & Nakaya, M. (2020, July 1). Efferocytosis during myocardial infarction. Journal of Biochemistry. Oxford University Press. https://doi.org/10.1093/jb/mvaa051

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free