Malonyl-based chemosensors: Selective detection of Fe3+ Ion Aqueous Medium

Abstract

Two novel malonyl-based chemosensors. AyT-bis(ethyI-4'-benzoate)-I.3-propanecu'amide II) and N'N"-bis(eihyl-3'-benzoate)-I.3-propanediamide 12), have been synthesized and screened towards various biologically important metal ions such as, and. The emission spectral studies of both I and 2 displayed 84-91% turn-off emission responses selectively with Fe ion in aqueous buffer (MeCN/HjO. 1:4, v/v. pH = 7.4) solution. Chemosensors I and 2 exhibited remarkable sensing ability towards Fe ion over other metal ions with limit of detection (LOD) of 4.28 and 4.33) ".M. respectively. The binding stoichiometry of I and 2 with ion was studied by Be nesi-Hilde brand fitting. Stern-Volmer plot and Job's plots, revealing that both chemosensors (I-2) bind with metal ion in 1:1 stoichiometric ratio with the apparent association constant (Ka) 8.90 x 103 and 11.16 x 103 M-1. respectively. Furthermore, the interactions of chemosensors (I-2) with metal ion were also investigated by using density functional theory (DFT) at B3LYP hybrid functional using 6-31G and LanL2DZ basis sets.