Auditory brainstem response in premenopausal women taking oral contraceptives

Abstract

Background: The aim of this prospective study was to evaluate the effects of the new monophasic oral contraceptives on the audiological system in premenopausal women. Methods: The auditory brainstem response (ABR) was measured in 94 women during the follicular, periovular and luteal phases of one menstrual cycle in which ovulation was confirmed using sonography and serum progesterone concentration. The latencies for waves I, III and V were determined, and the inter-peak intervals were calculated for waves I-III, I-V and III-V. All 94 women began taking oral contraceptives: 23 women used 20 μg ethinyl estradiol (EE) plus 150 μg desogestrel, 24 women used 30 μg EE plus 75 μg gestodene, and 47 women used 15 μg EE plus 60 μg gestodene. During the third month of contraceptive intake, each subject was again tested for ABR, as above. Results: The wave latencies and inter-peak intervals showed shorter values during the periovular phase with respect to the luteal phase (P < 0.05), the follicular phase for wave I and for inter-peak interval I-V (P < 0.05) of the menstrual cycle. All of the ABR results in pill users were statistically different from those of the periovular phase (P < 0.05), though similar to those of both the luteal and follicular phases (P = NS). Conclusions: ABR seems to depend on the variations of ovarian steroids during the menstrual cycle and during oral contraceptive intake.