GSTP1 and CYP1A1 gene polymorphisms and non-hodgkin lymphoma

Abstract

Objective: To determine the association between genetic variants of GSTP1 and CYP1A1 enzymes and individual susceptibility to diffuse large B-cell lymphoma (DLBCL), as well as correlations with tobacco smoking. Methods: Fifty patients with DLBCL and 50 apparently healthy volunteers were genotyped for detection of GSTP1 and CYP1A1 polymorphisms by the restriction fragment length polymorphism (RFLP) technique. Results: For GSTP1 313 A→G polymorphism, statistically significant differences were observed between the DLBCL and control groups for the AA, AG, and GG genotypes, as well as the G allele. For CYP1A1 4889 A→G (M2) polymorphism, statistically significant differences were observed for the AA and AG genotypes and the G allele. The relationship of smoking status to susceptibility to DLBCL in the presence of these genetic polymorphisms revealed that smoking status had no effect. Conclusion: GSTP1 313 A→G polymorphism is associated with a decreased risk of lymphoma, whereas CYP1A1 4889 A→G (M2) polymorphism is associated with an increased risk of lymphoma regardless of smoking status. © 2012 by The American Society for Clinical Pathology.