Computer Simulation of Trabecular Remodeling Considering Strain-Dependent Osteosyte Apoptosis and Targeted Remodeling

Abstract

Bone structure is deeply related to its mechanical function, and is maintained adaptation by remodeling. Among many investigations concerning the mathematical modeling of bone remodeling, the physiological range of mechanical stimuli has been studied mainly. In this study, mathematical models of surface remodeling in disuse and overuse windows are formulated by paying attention to the osteocyte apoptosis and targeted remodeling, and are unified with that in the physiological window. The fundamental characteristics of the unified model are examined through numerical cases. © 2009 International Federation of Medical and Biological Engineering.