Konjac Glucomannan: A Functional Dietary Fiber for Gut Health, Metabolic Regulation, and Clinical Applications – A Comprehensive Review

Abstract

This study aims to review the potential of Konjac Glucomannan (KGM) as a functional dietary fiber in improving digestive health, regulating metabolism, and its clinical applications. The focus is on KGM's benefits in weight management, glycemic control, and modulation of gut microbiota. A comprehensive literature review was conducted to examine various studies on KGM's extraction methods, structural composition, physiological effects, and clinical uses. The review also addresses KGM’s regulatory status and safety to ensure appropriate dosing standards and long-term efficacy. Results demonstrate that KGM forms a gel matrix in the gastrointestinal tract, promoting satiety, reducing glucose absorption, and influencing lipid metabolism. Additionally, KGM exhibits prebiotic properties that support beneficial gut microbiota and enhance gut barrier integrity through the production of short-chain fatty acids (SCFAs). KGM's role in improving metabolic health and digestive function highlights its potential as a promising dietary fiber. Future research should focus on optimizing KGM formulations, exploring its role in personalized nutrition based on microbiome composition, and investigating its impact on neurological and metabolic disorders. This review emphasizes the need for further clinical trials to better understand KGM's therapeutic applications and long-term effects in promoting health and preventing disease.