Antinociceptive and Anti-Inflammatory Activities of Ethanol Extract of Bryophyllum Pinnatum Laboratory Animals

Abstract

The ethanol extract of Bryophyllum pinnatum was investigated for possible anti-nociceptive and anti-inflammatory effects in mice and rats was carried out using acetic acid-induced abdominal contractions in mice and formalin-induced hind paw edema in rats. . Three doses of the extract (50, 100, and 200mg/kg body weight) were used intraperitoneally for both anti-nociceptive and anti- inflammatory studies. There was a significant effect (P<0.05) for the anti-nociceptive study, the highest activity resides at the lowest dose 50mg/kg body weight of the extract, while for the anti-inflammatory study (P<0.05) the activity resides more at the dose of 100mg/kg. Preliminary phytochemical screening of the extract revealed the presences of alkaloid, triterpenoid, saponin, glycerin, flavonoid,, glycerin and steroid. The intraperitoneal LD50 is 774 mg/kg body weight in mice. The results support the local use of the plant in painful and inflammatory condition.