Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism

Abstract

Apigenin 7-O-β-D-glucopyranuronide (1), luteolin 7-O-β-D- glucopyranuronide (2), m-hydroxybenzyl β-D-glucoside (3), and chrysoeriol 7-O-β-D-glucopyranuronide (4) were isolated for the first time from the leaves of Salix matsudana. Furthermore, the effects of compounds 1, 2 and 3 on arachidonic acid metabolism were studied. These compounds inhibited significantly the production of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE). In addition, the aglycon apigenin inhibited not only 12-HETE but also thromboxane B2 (TXB2). The effect of compound (4) on arachidonic acid metabolism is now under investigation. © 2005 The Pharmaceutical Society of Japan.