Synthesis, antimicrobial and cytotoxicity studies of some novel modified strobilurin derivatives

Abstract

A series of some new 3-isoxazoline substituted methyl-3-methoxy-2-(4-oxo-3, 4-dihydrophthalazin-1-yl)prop-2-enoate derivatives were designed and synthesized from methyl-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate, which in turn was prepared from phthalic anhydride. The structures of synthesized new compounds were characterized by spectral data and studied for their antimicrobial activities and cytotoxicity. Several of these compounds showed good antimicrobial activity. © 2011 Sociedade Brasileira de Química.