Mir-17-92 cluster targets phosphatase and tensin homology and ikaros family zinc finger 4 to promote th17-mediated inflammation

Abstract

Background: miRNA is a key component of post-transcriptional network governing the fate of T cells. Results: By targeting PTEN and IKZF4, miR-17-92 cluster promotes TH17 differentiation and TH17-related inflammation. Conclusion: miR-19b and miR-17 within the cluster additively promote TH17 responses through distinct regulatory networks. Significance: Our study provides novel regulatory mechanisms and potential therapeutic candidates against autoimmunity. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.