Abstract
Vagal Nerve Stimulation (VNS) is an option in the treatment of drug-resistant epilepsy. However, approximately a quarter of VNS subjects does not respond to the therapy. In this retrospective study, we introduce heart-rate features to distinguish VNS responders and non-responders. Standard pre-implantation measurements of 66 patients were segmented in relation to specific stimuli (open/close eyes, photic stimulation, hyperventilation, and rests between). Median interbeat intervals were found for each segment and normalized (NMRR). Five NMRRs were significant; the strongest feature achieved significance with p=0.013 and AUC=0.66. Low mutual correlation and independence on EEG signals mean that presented features could be considered as an addition for models predicting VNS response using EEG.
Cite
CITATION STYLE
Plesinger, F., Halamek, J., Chladek, J., Jurak, P., Dolezalova, I., Chrastina, J., & Brazdil, M. (2020). Response to Vagal Stimulation by Heart-rate Features in Drug-resistant Epileptic Patients. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2020-July, pp. 46–49). Institute of Electrical and Electronics Engineers Inc. https://doi.org/10.1109/EMBC44109.2020.9176326
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
