BEt3-Initiated Thiol-Ene Click Reactions as a Versatile Tool to Modify Sensitive Substrates

Abstract

BEt3-initiated thiol-ene click reactions are an interesting alternative to the generally used thermal or photochemical thiol additions. The reactions proceed under very mild conditions, and require only 10 mol-% of BEt3, and an almost stoichiometric amount of thiol. In this regard, this method is an attractive alternative to the other protocols, which often use the thiol component in a large excess. BEt3-initiated thiol-ene click reactions proceed under very mild conditions, and require only 10 mol-% of BEt3 and an almost stoichiometric amount of thiol. The mild reaction conditions allow the modification of substrates containing functionalities that are senstitive to H-abstraction.