Antibiotic resistance patterns of pediatric Typhoid fever at the Department of Child Health, Hasan Sadikin General Hospital, Bandung

Abstract

We reviewed bacteriologically confirmed typhoid fever patients, hospitalized in our department from July 1, 1994 to June 30, 1997. There were 50 cases who were evaluated for antibiotic resistance patterns. Blood culture was carried out using Kirby-Bauer dffusion method. The determination of bacteriological sensitivity was carried out using criteria established by The National Committee for Clinical Laboratory Standards (NCCLS). Result of sensitivity test showed that 85.4% (41/48) were sensitive to chlorantphenicol; 88.8% (40/45) to ampicillin; 91.6% (22/24) to amoxycillin; 83.65% (41/49) to co-trimoxazole, and 96.0% (48/50) to ciprofloxacin. Number of isolates which resistant to these antibiotics were 10.4%, 6.6%, 8.4%,10.2% and 4.0%, respectively. The other results were intermediate. Three isolates o/ Salmonella typhi were resistant to three antibiotics (chloramphenicol, ampicillin and co-trimoxazole). According to antibiotics which administered firstly to the patients, there was no apparent synchronization between in vitro sensitivity with in vivo clinical response in 10 (20%) patients