Estudio experimental sobre la regeneración ósea mandibular de la rata con diferentes biomateriales

Abstract

Mandibular bone defects can occur as a result of trauma, neoplasm, or infectious conditions. Such conditions often are associated with severe funtional and esthetic problems. Corrective treatment often is complicated by limitations in tissue adaptation. The aim of this study was to compare new bone formation following application of a bioabsorbable membrane and two types of bone substitutes. Material and method. In the present study, 24 fourmonth-old male Wistar rats were used. Standardized round throughand-through bone defects (4 mm in diameter) were made in both mandibles and the rats were divided into four groups: one control group and 3 experimental groups. Animals were killed 3 and 6 weeks after surgery. Bone defect healing was assessed by radiologic and histologic analysis. Results. The control defects showed no bone formation; holes were filled with fibrous connective tissue. Bone membrane alone was an efficient barrier, excluding nonosteogenic tissue. However, new bone formation underneath the membrane was incomplete. The Colloss® + membrane group showed complete healing after 6 weeks. The NovaBone® + membrane group showed no bone formation and particles appeared in the defect. Conclusions. The percentage bone regeneration was significantly better in the defects filled with Colloss® and covered with Lambone® than the other experimental groups. © 2008 ergon.