Abstract
Background: The MLL1 core complex mono-and dimethylates histone H3 lysine 4 (H3K4). Results: MLL1 automethylates a conserved cysteine residue in its active site cleft. Conclusion: MLL1 automethylation is inhibited by unmodified histone H3 but not by histones previously mono-, di-, or trimethylated at H3K4. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Patel, A., Vought, V. E., Swatkoski, S., Viggiano, S., Howard, B., Dharmarajan, V., … Cosgrove, M. S. (2014). Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a “two-active site” model for multiple histone H3 lysine 4 methylation. Journal of Biological Chemistry, 289(2), 868–884. https://doi.org/10.1074/jbc.M113.501064
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