Steeping of ginger (Zingiberofficinlae roscoe) potentially decrease the risk of atherosclerosis by attenuate of tumor necrosis factor (TNF)-α expression

Abstract

Cardiovascular disease still one of the highest death factor in Indonesia. Ginger as an antiatherosclerosis could be one of the alternatives that is being developed to decrease the cardiovascular disease. The general aims of this research were determining the mechanism of ginger as anti-atherosclerosis to decrease the risk of cardiovascular disease. Research design used was “The Randomized Posttest only Control Group Design”. In this research, the experimental unit was Rattus norvegicus, male; in the age of 3 months and total number were thirty. Independent variable of this research was steeping of ginger, the dose various of steeping ginger (control, 1g, 3g, 3g + bay leaf, and 5g), and dependent variable was Tumor Necrotic Factor (TNF)α of tissue lipid. TNF α expression was measured by using ELISA method. The data was analyzed by using ANOVA. Based on the analysis, it showed that steeping of ginger was decreased the expression of TNF-α in fat tissue (1g = 551 pg/mL, 3g = 511 pg/mL, 3g + bay leaf = 493 pg /mL) compare to control (986.8 pg/mL) but on the 5 g dose there is contradictory effect that is there is increasing TNF α (1103.5 pg/mL). Conclusion, steeping of ginger potentially decrease the risk of atherosclerosis by attenuate of TNF α expression.