Exenatide has been widely used for the treatment of type 2 diabetes mellitus. However, its short plasma half-life of 2.4 hours has limited its clinical application. The exenatide products on the market, twice-daily Byetta™ and once-weekly Bydureon™ (both Amylin Pharmaceuticals, San Diego, CA, USA), are still not perfect. Many researchers have attempted to prolong the acting time of exenatide by preparing sustained-release dosage forms, modifying its structure, gene therapies, and other means. This review summarizes recent advances in long-acting exenatide preparations. © 2013 Cai et al.
CITATION STYLE
Cai, Y., Wei, L., Ma, L., Huang, X., Tao, A., Liu, Z., & Yuan, W. (2013, September 4). Long-acting preparations of exenatide. Drug Design, Development and Therapy. https://doi.org/10.2147/DDDT.S46970
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