Multicycle infection of hepatitis C virus in cell culture and inhibition by alpha and beta interferons

  • Shimizu Y
  • Yoshikura H
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Abstract

We previously reported that a clone of a human lymphocytic cell line, HPBMa clone 10-2, supports the genome replication of hepatitis C virus (HCV). In the present study, the multicycle transmission of HCV from infected cells to new cells was demonstrated by coculture with drug-resistant cells as recipients; i.e., the system was proved productive for infectious HCV. Inhibition of viral replication by alpha and beta interferons was observed.

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Shimizu, Y. K., & Yoshikura, H. (1994). Multicycle infection of hepatitis C virus in cell culture and inhibition by alpha and beta interferons. Journal of Virology, 68(12), 8406–8408. https://doi.org/10.1128/jvi.68.12.8406-8408.1994

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