Current perspectives on glioblastoma treatment synergies between therapies and delivery systems

Abstract

In adults, glioblastoma multiforme (GBM) is considered the most widespread and virulent malignancy of the central nervous system (CNS). This formidable brain tumor stands out as one of the most lethal types within the CNS cancer classification. Despite ongoing advancements in modality therapy, a curative solution remains largely unattainable. Consequently, the imperative to develop innovative systems, plans, and treatment strategies for expanding the repertoire of efficacious agents targeting GBM has emerged as a critical research priority. Presently, oncological research mostly concentrates on enhancing the treatment of glioblastoma multiforme using various innovative drug delivery technologies. Multiple therapies are available at diagnosis, including radiation therapy. New therapeutics are emerging due to breakthroughs in understanding the molecular pathophysiology of GBM and associated cell signaling networks. This comprehensive review examines cutting-edge drug delivery systems and therapeutic approaches for the management of GBM. The innovative methodologies and treatment strategies discussed demonstrate enhanced accuracy, favorable safety profiles, and encouraging effectiveness, potentially paving the way for a revolutionary approach to GBM elimination.