Anti‐emetic effect of high‐dose metoclopramide vs alizapride—a randomised crossover study.

Abstract

A randomised double‐blind crossover study was undertaken to compare the anti‐emetic efficacy of alizapride against high dose metoclopramide. A total of 32 patients on cisplatin were randomised to receive either high dose metoclopramide (7 mg kg‐1 day‐1) or alizapride (5 mg kg‐1 day‐ 1). Anti‐emetic responses in terms of control of vomiting episodes were similar in both regimens (59%). However, patients showed a statistically significant preference for high dose metoclopramide (P = 0.02). Side effects of both regimens were minimal. We conclude that alizapride is not superior to high dose metoclopramide in controlling cisplatin induced vomiting. 1994 The British Pharmacological Society