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An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration

Journal of Biological Chemistry (2013) 288(40) 28656-28667
DOI: 10.1074/jbc.M113.509505
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Abstract

Background:CXCR4/CXCL12 axis provides directional cues for breast cancer cells to metastasize to specific organs. Results:LIP regulates the expression of CXCR4, promoting CXCR4/CXCL12-mediated breast cancer cell migration. Conclusion:LIP is a previously unrecognized transcriptional regulator of CXCR4. Significance:Our results revealed a potential link between heregulin, LIP, and CXCR4 and may have important therapeutic implications for metastatic breast cancer. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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Park, B. H., Kook, S., Lee, S. B., Jeong, J. H., Brufsky, A., & Lee, B. C. (2013). An isoform of C/EBPβ, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration. Journal of Biological Chemistry, 288(40), 28656–28667. https://doi.org/10.1074/jbc.M113.509505

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