Fatal dapsone agranulocytosis in a Melanesian

Abstract

The death from agranulocytosis and septicaemia of a young Melanesian male receiving unsupervised treatment with 100 mg daily of dapsone for indeterminate leprosy is reported. The historical recognition and clinical management of agranulocytosis resulting from dapsone is discussed. Careful observation of leprosy patients for side-effects during the initial weeks of treatment is recommended. This may include hospital admission and regular blood counts when possible.