The Effect of Cigarette Smoke Exposure with Bidara (Sidr) Leaf Powder Biofilter on Glucose Levels and Pancreas Histology in Mice Diabetes Mellitus

Abstract

Cigarette smoke free radicals are chemical compounds that are harmful to the health of the body. Diabetics have high levels of oxidative stress due to excess free radicals and lack of antioxidants, so antioxidants are needed to stabilize free radicals in the body. The results of previous studies showed that 0.9 gram bidara (Sidr) leaf powder biofilter was able to capture free radicals in cigarette smoke. The purpose of this study was to examine the effect of exposure to cigarette smoke with a biofilter of bidara leaf powder on blood glucose levels and pancreatic histology in diabetic mice. The sample in this study used five treatment groups, previously induced with streptozotocin to become diabetic. Exposure to cigarette smoke was carried out for 3 weeks, every week checking blood sugar. After that the mice were dissected to observe the histology of the pancreas. Statistical results using One way ANOVA showed that there was an effect of exposure to cigarette smoke with a biofilter made from bidara leaf powder on blood glucose levels and pancreatic histology in diabetic mice.