High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains

  • Loes A
  • Tarabi R
  • Huddleston J
  • et al.
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Abstract

We describe a new approach that can rapidly measure how the antibodies in human serum inhibit infection by many different influenza strains. This new approach is useful for understanding how viral evolution affects antibody immunity. We apply the approach to study the effect of repeated influenza vaccination.

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Loes, A. N., Tarabi, R. A. L., Huddleston, J., Touyon, L., Wong, S. S., Cheng, S. M. S., … Bloom, J. D. (2024). High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains. Journal of Virology, 98(10). https://doi.org/10.1128/jvi.00689-24

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