A microwave-assisted domino rearrangement of propargyl vinyl ethers to multifunctionalized aromatic platforms

Abstract

H makes a difference! A novel reactivity profile of propargyl vinyl ethers has been developed, which is controlled by the presence of a hydrogen atom at the homopropargylic position (see scheme; EWG=electron-withdrawing group). This strategy was conveniently used to construct multifunctionalized phenolic platforms, including salicylaldehydes and the corresponding ketone derivatives. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.