Brain Metastases of Malignant Melanoma Showing Unbalanced Whole Arm Chromosomal Translocations der (8; 14) (q10; q10) and der (11; 15) (q10; q10) in a Japanese Patient

Abstract

Since malignant melanoma is a rare malignancy in Japan, little is known about the cytogenetic abnormalities in Japanese patients. We report a case of malignant melanoma showing complex chromosomal abnormalities. A 70-year-old woman was admitted to our hospital because of anorexia, delirium, and right hemiplegia. Cranial CT disclosed several metastatic brain tumors. Multiple subcutaneous and intra-abdominal metastases were also found. A diagnosis of metastatic malignant melanoma was made by biopsy of a subcutaneous tumor. Chromosomal analysis of the tumor cells disclosed complex karyotypic abnormalities including novel unbalanced whole arm translocations der (8; 14) (q1O; q1O) and der (11; 15) (q1O; q1O). © 2001, The Japanese Society of Internal Medicine. All rights reserved.