The use of aromatase inhibitors in infertility and gynecology

Abstract

Aromatase inhibitors act by blocking the aromatization of androgen to estrogen. Although the concentration of estrogen is decreased, they do not have the antiestrogen effect of clomiphene. This makes them ideal for ovulation induction and controlled ovarian hyperstimulation. Owing to their ability to decrease estrogen concentration, aromatase inhibitors could also be used for estrogen-dependent conditions including endometriosis, myoma and adenomyosis. In addition, they could be useful for stimulation of follicle development in women with estrogen-dependent neoplasia who wish to preserve their fertility. © 2011 Expert Reviews Ltd.