AUTOMATED RECOGNITION OF DEPRESSION FROM FEWER-SHOT LEANING IN RESTING-STATE fMRI WITH ReHo USING DEEP CONVOLUTIONAL NEURAL NETWORK

Abstract

Up to now, there is still the absence of research about depression recognition using resting-state functional magnetic resonance imaging (rest_fMRI) and deep learning. Previous studies have shown that regional homogeneity (ReHo) of rest_fMRI (rest_ReHo_fMRI) is a characterization of the functional synchronization of adjacent voxels in brain regions, and the mental and behavioral abnormalities in depression are due to an imbalance of ReHo synchronization in some brain functional areas. Accordingly, this paper presents a method for depression recognition using rest_ReHo_fMRI. First, the rest_ReHo_fMRI is extracted from the preprocessed rest-fMRI by calculation. Then, deep convolutional networks (such as VGG16) pretrained on ImageNet are used to automatically complete extracting the classification features from rest_ReHo_fMRI. Finally, the Kernel Extreme Learning Machine (KELM) was used to classify the depression. The results of the test set show that the proposed method achieves 89.07% in sensitivity and 89.74% in specificity. This study suggests that features of rest_ReHo_fMRI can be used as biomarkers to distinguish depression from normal people.