Electrochemical determination of olmesartan medoxomil using hydrothermally prepared nanoparticles composed SnO2-Co3O4 nanocubes in tablet dosage forms

Abstract

Low-dimensional nanoparticles composed SnO2-Co3O 4 nanocubes (NCs) were prepared by a hydrothermal method using reducing agents. The doped nanomaterials were investigated by UV/vis, powder X-ray diffraction, FT-IR, energy-dispersive X-ray spectroscopy (EDS), and Raman spectroscopy, and field-emission scanning electron microscopy. They were deposited on a silver electrode (AgE, surface area, 0.0216 cm2) to give a drug sensor with a fast response towards Olmesartan medoxomil (OSM) in 0.1 mol L-1 phosphate buffer-phases. The sensor also exhibits higher sensitivity, long-term stability, and enhanced electrochemical response. The calibration plot is linear (r2=0.9948) over the 0.28 nmol L -1-1.4 μM OSM concentration range. The sensitivity is ∼2.083 μA cm-2 mmol L-1 and the detection limit is 0.17 nmol L-1 (at an SNR of 3). We discuss the possible potential uses of this nanoparticles doped semiconductor NCs in terms of drug sensing, which could also be employed for the determination of drugs in quality control of formulation. © 2012 Elsevier B.V.