Effects of General Anesthesia vs Regional Anesthesia on Neonatal Outcomes: A Systemic Review and Mata Analysis

Abstract

Backgrounds: Types of anesthesia provision and perioperative patient cares are the main determinants of neonatal outcome in mothers undergo caesarean section. Body of evidence didn’t clearly reveal which types of Anesthesia technique is associated with better neonatal outcomes in mothers who gave birth under spinal anesthesia than general anesthesia. The aim of this systemic review and meta-analysis was to compare neonatal outcomes in mothers who undergo caesarean section under general anesthesia and regional anesthesia. Methods: We carried out a systemic search of the electronic databases of central, Medline, Embase, LILACS, AOLJ and others with PICO strategy for controlled clinical trials comparing neonatal outcomes under general and regional anesthesia. Twenty trials were identified for eligibility assessment, ten trials were selected for data extraction, and nine trials were finally included in the meta-analysis. All controlled clinical trials using regional and general anesthesia for ASA I-II term pregnant women coming for cesarean section in elective and semi-urgent condition were selected. Eligibility assessment was performed independently by the two review authors using a customized form, while discrepancies were resolved by consensus. The Data from individual trial were extracted and entered Review Manager for synthesis.